England have named Elliot Daly in place of Jonathan Joseph at outside centre for Saturday's autumn opener against South Africa at Twickenham.
Daly makes his full Test debut after winning five caps as a replacement, forming a new midfield partnership alongside Owen Farrell that offers long-range left and right-footed kicking options.
It is the first time Joseph, a veteran of 25 internationals, has been dropped since establishing himself during the 2015 RBS 6 Nations and he drops to the bench to provide centre and wing cover.
Tom Wood ends a year-long spell in the international wilderness that began after last autumn's World Cup by filling the void at openside created by a succession of injuries.
Meanwhile, Jonny May also starts for the first time under Eddie Jones having recovered from a broken leg.
"We've picked a matchday 23 with a blend of experience and youth," head coach Eddie Jones said.
England team to face South Africa:
Brown; Yarde, Daly, Farrell, May; Ford, Youngs; Vunipola, Hartley (captain), Cole, Launchbury, Lawes, Robshaw, Wood, Vunipola
Replacements: George, Marler, Sinckler, Attwood, Hughes, Care, Te'o, Joseph
Daly set for first England start as May, Wood return
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